Neo Domino City and Satellite, formerly known collectively as Domino City, are what remains after Zero Reverse, a huge natural disaster, struck the region seventeen years ago. To the east, Neo Domino City is the symbol of hope for an ever-expanding world. To the west, Satellite is a wellspring of despair for those totally isolated within its social and geographical barrier.
Yusei Fudo, a Satellite native, grew up on the town’s desolate and broken streets, fending only for himself. As such, he finds his own method of living, in an abandoned subway tunnel no less, using only the junk he discovers.
Things take a turn as he completes his D-Wheel, a motorcycle-esque machine used for playing Duel Monsters in Riding Duels. He aims to get back what was stolen from him from an old comrade, Jack Atlas, who now reigns over the mainland city as duel king after having escaped Satellite.
In the very same vain, Yusei also plans to escape from Satellite as a way to achieve his goal. All the while, this duelist has a greater fate awaiting him.